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By Philip W. Harvey, David J. Everett, Christopher J. Springall

Despite being considered as the most typical toxicological objective within the endocrine process, the adrenal gland has frequently been overlooked in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes thoughts to be had to check adrenal endocrine disruption.

Examining present strategies and the most recent developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers info at the variety of substances and chemical substances that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro evaluate. This quantity additionally provides fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the key advancements remodeled the prior decade
  • focuses at the most modern study concepts, together with their makes use of and limitations
  • provides an built-in technique for adrenal toxicology evaluation
  • identifies wisdom and information gaps, supplying impetus for regulatory consideration

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Gen Comp Endocrinol 1968; 10:263–268. Soll RM, Dollings PJ, Mitchell RD, et al. Guanabenz-related amidinohydrazones: Potent non-azole inhibitors of aldosterone biosynthesis. Eur J Medicinal Chem 1994; 29:223– 232. Adrenal Toxicology 33 Sonino N, Boscaro M, Fallo F. Pharmacologic management of Cushing syndrome: New targets for therapy. Treat Endocrinol 2005; 4:87–94. Spindel E, Griffiths L, Wurtman RJ. Neuroendocrine effects of caffeine. II. Effects on thyrotropin and corticosterone secretion. J Pharmacol Exp Ther 1983; 225:346–350.

Harvey PW. Glucocorticosteroid modulation of toxicity. In: Harvey PW, ed. The Adrenal in Toxicology: Target Organ and Modulator of Toxicity. London: Taylor & Francis, 1996b:185–204. Healing G. Hormonal mechanisms in kidney toxicology. In: Harvey PW, Rush KC, Cockburn A, eds. Endocrine and Hormonal Toxicology. Chichester: John Wiley,; 1999:291– 307. Hecker M, Giesy JP. Novel trends in endocrine disruptor testing: The H295R steroidogenesis assay for identification of inducers and inhibitors of hormone production.

Toxicol Appl Pharmacol 2000; 179:1–12. Baldwin JA. Glucocorticosteroids, stress, and developmental toxicology. In: Harvey PW, ed. The adrenal in toxicology: Target organ and modulator of toxicity. London: Taylor & Francis; 1996:223—242. Baos R, Blas J, Bortolotti GR, et al. Adrenocortical response to stress and thyroid status in free-living nestling white storks (Ciconia ciconia) exposed to heavy metal and arsenic contamination. Environ Health Perspect 2006; 114:1497–1501. Barrett AM. Some factors affecting blood ACTH levels.

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