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By H. A. Wenner, A. M. Behbehani, L. Rosen (auth.)

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0 I " 0 P mild, febrile carditis ? s Y febrile + + P P + P+ + P p P carditis Y Y P+ + + P P + P P pI P P P ? 9 ~ :8... P P+ P + P P P Respi· ratory fatal P P P P febrile none' none' febrile 'I + I definite association; P, presumptive association; data. A. Wenner and A. Behbehani: ECHO Viruses gastro-intestinal and/or respiratory systems. Occasionally cerebellar ataxia, peripheral neuropathies, hepato-renal dysfunction, orchitis, pleurodynia or carditis may intervene during infections involving several serotypes (Table 4).

BUSER et al. (1957) recovered type 4 virus from a 32-year-old woman with bilaterallimb paralysis. , 1958; FOLEY et al. , 1959; PLAGER and HARRISON, 1961; REINHARDT, 1963) have reported similar episodes in children and adults for types 9 and 14. , 1964) about 5% of the group with CNS disease from ECHO 30 developed limb and Interactions with Man and Other Mammalian Species 37 truncal paralysis. , 1962). Muscular dysfunction of lesser severity however is the rule, chiefly involving neck, trunk and girdle muscles.

1961). Using rabbit antiserum, LAHELLE (1958b) observed a one-way cross between these latter types; he also noted reciprocal crossing between types 3 and 13. A. lYL Behbehani: ECHO Viruses b) Crosses Encountered with Human Sera Infection of human beings with several enteroviruses may evoke heterotypic serologie al responses. Such responses have been obtained more often by CF than by serum neutralization. The following accounts illustrate some of the findings. CF antibodies for ECHO virus types 6 and 9 followed infection with type 4 (JOHNSSON et al.

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