Download Hormones and Signaling by Lutz Birnbaumer, James Darnell, Ronald Evans, Tony Hunter, PDF

By Lutz Birnbaumer, James Darnell, Ronald Evans, Tony Hunter, Anthony R. Means, Vale Wylie, Bert W. O'Malley

Hormones and Signaling makes a speciality of the mechanism of gene law on the mobile point. It additionally covers the way in which hormones act to modulate gene law and animal improvement. Key beneficial properties* contains details on:* Nuclear receptors, coactivators, and corepressors* Membrane receptors, kinases, and phosphorylation on cascades* Hormonal rules of improvement* Calcium channels and neurotransmitters* Chromatin, transcription components, and law of gene expression* JAK/STAT pathways* Hormone-regulated improvement and gene "knock-out"

Show description

Read Online or Download Hormones and Signaling PDF

Best endocrinology books

The Osteoporosis Primer

Osteoporosis is likely one of the prime reasons of morbidity and mortality one of the aged. the reason for The Osteoporosis Primer is to supply an introductory textual content that relates the medical presentation of osteoporosis to its molecular biochemical foundation. The textual content has been prepared into 4 sections that take care of the molecular/cellular parts of bone, the advance of height bone mass, the pathophysiology of getting older bone and eventually, how all of those relate to the prevention, prognosis, and remedy of osteoporosis.

Endocrinology

Desk 19. neighborhood structural results of endocrine ailments Endocrine indicators and indicators are hardly ever particular. This truth renders the artwork of spotting an endocrine constitution affected characteristic sickness in a sufferer extra usually one among suspecting instead of 'diagnosing' it. not like such a lot different physique Hypothalamus complications Pituitary complications, visible disorder 'systems' the very nature of the endocrine approach Thyroid strain indicators, dysphagia, guarantees that the consequences of disordered functionality in a goitre gland have an effect on the physique as an entire and reason diffuse Gonads Testicular lumps, ovarian plenty indicators and indicators.

Additional info for Hormones and Signaling

Example text

40. Thompson, E. , and Lippman, M. E. (1974). Mechanism of action of glucocorticoids. Metab. Clin. Exp. 23, 159-202. 41. Gruol, D. , Rajah, F. , and Bourgeois, S. (1989). Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in routine T-lymphoma cells. Mol. Endocrmol. 3, 2119-2127. 42. , McConkey, D. , and Okret, S. (1995). Thymocyte apoptosis by glucocorticoids and cAMP. Curr. Top. Microbiol. Immunol. 200, 67-79. 43. Saeed, M. F. (1995). Synergistic interaction between the glucocorticoid and the cAMPdependent protein kinase pathways in human leukemic cells.

When the ligand-binding domain of the GR is removed completely, the residual peptide becomes constitutively lethal, with much more rapid kinetics than the holoreceptor plus steroid. Thus, such truncated peptides may be causing cell death by another pathway. Such an effect is of interest for its potential in therapy of leukemias. Questions of 32 E. Brad Thompson optimization of potency and targeted delivery of this GR fragment remain to be addressed. In cells with functional GR the standard glucocorticoid-evoked death pathway causes cells to become irreversibly trapped in G0/G1, and DNA lysis into specific large and small forms occurs.

50(2), 440-444. 21. Thompson, E. B. (1997). Glucocorticoids and apoptosis of hemopoietic cells: Transcriptional and post-transcriptional control. In "Inhaled Glucocorticoids in Asthma Mechanisms and Clinical Actions" (R. P. Schleimer, W. W. Busse, and P. M. ), pp. 81-106. Dekker, New York. 22. , and Ringold, G. (1981). Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumor virus chimaeric plasraids. Nature (London) 294, 228-232. 23. Ringold, G. M. (1985). Steroid hormone regulation of gene expression.

Download PDF sample

Rated 4.84 of 5 – based on 34 votes