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By T Honjo; Frederick W Alt; M S Neuberger

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And Hamlyn, P. H. (1983). Nature 306, 806–9. Ramsden, D. , McBlane, J. , van Gent, D. , and Gellert, M. (1996). EMBO J 15, 3197–3206. Ravetch, J. , and Leder, P. (1981). Cell 27, 583–591. , and Weill, J. C. (1987). Cell 48, 379–388. , Cohen, J. , D. (1982). Proc Natl Acad Sci U S A 79, 4405–4409. , and Alt, F. W. (1986). EMBO J 5, 2131–2138. , Koop, B. , and Hool, L. (1996). Science 272, 1755–1762. , and Capra, J. D. (1989). J Immunol 142, 883–887. Sasso, E. , van Dijk, K. , Bull, A. , and Milner, E.

All rights reserved. 1 Neighbor-joining tree of the C57BL/6 Vh gene segments. The 101 candidate functional Vh genes group into three major clades (the subgroups of Kabat) and 15 Vh gene families. The Vh gene coding sequences corresponding to the mature heavy chain peptide were extracted from the mouse genome assembly. Apparent pseudogenes containing termination codons were omitted. , 1997); the tree was plotted with DrawGram in the PHYLIP package (Felsenstein, 1993). similar gene family organization and content in C57BL/6 and many different Igh haplotypes in lab strains and wild mice (Tutter and Riblet, 1988; Tutter and Riblet, 1989b).

Proc Natl Acad Sci U S A 86, 5035–5038. , and Cogne, M. (1996). Palindromic structure of the IgH 3¢locus control region. Nat Genet 14, 15–16. , Herring, C. , and Riblet, R. (2002). A threemegabase yeast artificial chromosome contig spanning the C57BL mouse Igh locus. J Immunol 168, 5659–5666. , and Sen, R. (2001). Stepwise activation of the immunoglobulin mu heavy chain gene locus. EMBO J 20, 6394–6403. Cook, G. , Tomlinson, I. , Carter, N. , and Rabbitts, T. H. (1994). A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q.

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