Download Natriuretic Peptides by Aldo Clerico, Michele Emdin PDF

By Aldo Clerico, Michele Emdin

Modern cardiovascular technology has produced a innovative new proposal: the center acts now not in basic terms as a pump, yet as a "gland", that's as a regulator of circulatory homeostasis and salt-water stability. This ebook combines the classical heamodynamic view with the hot neuro-hormonal paradigm, in all its power medical implications. The e-book will curiosity physiologists and clinicians considering the examine of the cardiovascular method and care of middle patients.

Show description

Read Online or Download Natriuretic Peptides PDF

Similar endocrinology books

The Osteoporosis Primer

Osteoporosis is likely one of the prime motives of morbidity and mortality one of the aged. the explanation for The Osteoporosis Primer is to supply an introductory textual content that relates the scientific presentation of osteoporosis to its molecular biochemical foundation. The textual content has been geared up into 4 sections that care for the molecular/cellular elements of bone, the improvement of top bone mass, the pathophysiology of getting older bone and eventually, how all of those relate to the prevention, prognosis, and remedy of osteoporosis.

Endocrinology

Desk 19. neighborhood structural results of endocrine illnesses Endocrine signs and indicators are infrequently particular. This truth renders the artwork of spotting an endocrine constitution affected function sickness in a sufferer extra frequently one among suspecting instead of 'diagnosing' it. in contrast to such a lot different physique Hypothalamus complications Pituitary complications, visible disorder 'systems' the very nature of the endocrine method Thyroid strain signs, dysphagia, guarantees that the consequences of disordered functionality in a goitre gland have an effect on the physique as an entire and reason diffuse Gonads Testicular lumps, ovarian plenty indicators and indicators.

Extra resources for Natriuretic Peptides

Example text

Although it probably binds ATP and contains many residues conserved in the catalytic domain of protein kinases, kinase activity has not been detected [165]. It represses the enzyme activity of the catalytic cGMP-synthesizing domain and at the same time is necessary for its ligand-dependent activation [154]. The coiled-coil hing region is involved in receptor dimerization, which is also essential for the activation of the catalytic domain [165]. The cGMP produced modulates the activity of specific downstream regulatory proteins, such as cGMP-regulated phosphodiesterases, ion channels and cGMP-dependent Fig.

In contrast, other studies performed in cultured glomerular mesangial and renomedullary interstitial cells from the rat or Chinese hamster ovary cells reported that NPR-A is a constitutively membraneresident protein that neither undergoes endocytosis nor mediates lysosomal hydrolysis of ANP [188, 189]. A more recent study using 293T cells suggested that NPR-A and NPRB are neither internalized nor degraded in response to receptor occupation [173]. Further studies are necessary to clarify whether or not ANP binding to NPR-A stimulates its internalization, and whether this process is tissue- and/or species-specific.

These studies suggest that normal ventricular myocardium may produce only a limited amount of BNP in response to an acute and appropriate stimulation, probably via a constitutive secretory pathway, while the amount of hormone produced and secreted after chronic stimulation could be greatly increased via an upregulated secretory pathway. However, further studies are necessary in order to confirm the presence of secretory granules in human ventricular cardiomyocytes and in particular to evaluate their peptide content and pathophysiological relevance.

Download PDF sample

Rated 4.76 of 5 – based on 7 votes